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Showing posts with label heart. Show all posts
Showing posts with label heart. Show all posts

Thursday, May 30, 2013

Report questioning salt guidelines riles heart experts

By Maggie Fox, Senior Writer, NBC News

An unusual medical brawl erupted on Tuesday when the influential Institute of Medicine issued a report questioning the basis of years of advice for Americans to cut their salt intake in half.

The Institute, which advises the federal government on medical issues, concluded that the studies have answered the question poorly.? A panel of experts looked at studies showing the medical effects of eating too much salt, as well as at studies that have been used to suggest that some people may suffer form eating too little salt.

Its finding: There’s enough evidence to support advising Americans to keep sodium to 2,300 milligrams a day or less, but there’s not enough to support the current, lower target of 1,500 milligrams a day.

“There is evidence to lower excessive salt intake,” Dr. Brian Strom, a professor of medicine, epidemiology and biostatistics at the University of Pennsylvania, who chaired the panel, told reporters.

There is also good evidence that lowering intake to around 2,300 milligrams a day decreased the risk of heart disease,” Strom said. But he said that the evidence was absent to support recommendations of taking it as low as 1,500 milligrams a day. And, he said, there were some studies suggesting this could harm some people -- although those studies are also flawed.

This infuriated the American Heart Association.

“While the American Heart Association commends the IOM for taking on the challenging topic of sodium consumption, we disagree with key conclusions,” Heart Association CEO Nancy Brown said in a statement.

“The report is missing a critical component -- a comprehensive review of well-established evidence which links too much sodium to high blood pressure and heart disease.”

The Institute agrees that Americans eat far too much salt -- more than 3,400 milligrams a day on average. Most is “hidden” salt, in processed foods such as bread and cereal, restaurant meals and especially fast food.

And studies clearly show that salt raises blood pressure and that cutting salt can lower blood pressure. High blood pressure damages blood vessels and can lead to stroke, kidney failure and heart failure.

“We knew about all this data and it didn’t change our thinking,” said Dr. Elliott Antman of Brigham and Women’s Hospital and Harvard? Medical School . “We have to take the evidence that we have -- which is strong,” added Antman, a spokesman for the American Heart Association.

Several studies have suggested that about a quarter of Americans are salt-sensitive -- that their blood pressure is directly and immediately affected by how much salt they eat. But this doesn’t mean that the other 75 percent can pile on the salt with impunity, Antman said.

“About 90 percent of the population will ultimately develop hypertension as they age,” he said. “Part of this is almost certainly from years of eating too much salt, he added. Eating too much salt can also affect kidney function, he said.

An aggressive reduction in sodium is the way to go,” he said.

Strom would not be drawn into an argument. “What we are saying is the available data is not consistent on outcomes,” he said. “We are not saying that one shouldn’t be lowering excessive salt intake in the general population,” he added. ?“There is simply a lack of data showing it is beneficial.”

And, he said, it is not up to the panel to set a target. “It’s not that we are against (a target intake of) 1,500 milligrams,” he said. “The data are not consistent.”

The trouble with trying to measure salt intake is that it’s very hard to separate out salt from the rest of the? ingredients in food, said Antman.

A truly scientifically rigorous study would randomly assign people to eat diffferent amounts of salt daily and watch to see what kind of diseases they develop -- something that would be difficult to set up, police and also difficult to defend, ethically.

Antman says most Americans get their salt from prepared foods and from restaurants, not from at-home, scratch cooking. What’s needed, he said, is more encouragement for restaurants and food companies to lower sodium content of food.

The food industry argues that Americans have a taste for salt and they won’t buy products that are salt-free.? Antman agrees that it’s hard. ?“We are used to a high sodium content in our food,” he said.

“But the data say that in just two to three weeks you can train person’s taste buds to become accustomed to a lower sodium content in food.”

The Center for Science in the Public Interest piled on, too.

"What the committee failed to emphasize is that most Americans are deep in the red zone, consuming 3,500 to 4,000 milligrams of sodium a day,' the group, which publicizes calorie counts and other food risks, said in a statement.

"It's clear that those excessive levels increase the risk of high blood pressure, heart attacks, and strokes. Whether we aim for 2,300 or 1,500 milligrams a day is irrelevant until we move down out of the red zone. At restaurants, you can get roughly 2,000 milligrams of sodium from just one burrito, a single-serve pizza, or an order of kung pao chicken, and at least 1,000 milligrams from a typical sandwich or burger."

The Centers for Disease Control and Prevention has a widget on salt intake here.

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Saturday, May 25, 2013

Children With Heart Defects May Benefit From Carnitine Supplement

Main Category: Cardiovascular / Cardiology
Also Included In: Pediatrics / Children's Health;??Nutrition / Diet
Article Date: 11 May 2013 - 0:00 PDT Current ratings for:
Children With Heart Defects May Benefit From Carnitine Supplement
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A common nutritional supplement may be part of the magic in improving the survival rates of babies born with heart defects, researchers report.

Carnitine, a compound that helps transport fat inside the cell powerhouse where it can be used for energy production, is currently used for purposes ranging from weight loss to chest pain.

New research shows it appears to normalize the blood vessel dysfunction that can accompany congenital heart defects and linger even after corrective surgery, said Dr. Stephen M. Black, cell and molecular physiologist at the Vascular Biology Center at the Medical College of Georgia at Georgia Regents University.

"My hope is this is going to have a major, major impact on survival of babies," Black said. About half the babies born with heart defects have excessive, continuous high pressure on their lungs from misdirected blood flow. Early surgery can prevent full-blown pulmonary vascular disease, but scientists are finding more subtle disruptions in the signaling inside blood vessels walls that can be problematic - even deadly - up to 72 hours after surgery.

The good news is the changes are reversible and that carnitine speeds recovery and can even prevent the damage in a lamb model of these human heart defects, according to studies published in the journal Pediatric Research.

Normally, most blood flow bypasses the lungs in utero when the placenta provides blood and oxygen for the baby. Baby's first breaths naturally expand the lungs and blood vessels, activating a process inside the lining of vessels that enables them to accommodate the initial blood surge, then reduce pressure quickly, dramatically and permanently.

This natural transition doesn't occur when heart defects misdirect blood flow. "It's kind of like a chronic fetal-to-newborn transition," said Black, the study's corresponding author. Lungs get pounded with about three times the normal flow and, even when surgeries are done as early as possible to repair the defect, correct blood flow and protect the lungs, the 20 percent death rates from acute pulmonary hypertension have remained unchanged for a decade. "That's 1 in 5 kid (with this condition)," Black said.

Left unchecked, the barrage thickens blood vessels, making them unresponsive, much like those of an elderly individual who has lived for years with uncontrolled high blood pressure. The comparatively brief periods of pounding these babies experience impairs the ability of the endothelial cells, which line blood vessels, to produce nitric oxide, a major dilator of blood vessels.

The shear force disrupts carnitine homeostasis, weakens the mitochondria (the cell powerhouse) and impairs nitric oxide production. To make bad matters worse, the precursor to nitric oxide instead makes more peroxynitrite, prompting endothelial cells to grow and thickening blood vessels. Black was also corresponding author of a recent study in the Journal of Biological Chemistry that showed peroxynitrite does this by turning on the cell survival protein kinase Akt1.

The new study indicates that even without fixing the heart defect, high daily doses of carnitine in the first four weeks of life can prevent endothelial dysfunction. In fact, the laboratory lambs' ability to make nitric oxide is preserved even without the benefit of heart surgery and the responses to the chemical activity that enables blood vessel dilation is normalized, Black said.

Study co-author Dr. Jeffrey Fineman, a whole-animal physiologist and physician at the University of California, San Francisco, developed the model, a lamb whose four-chambered heart is very similar to humans. In utero surgery that misdirects too much blood to the lungs, means that, like children, the lambs are born with the defect.

Black is now working with Fineman, who is pursuing additional funding to resolve questions such as the optimal dosage and timing for giving carnitine. "Do you want to give it for six weeks when you only have to give it for six hours?" Black said. The researchers also plan to examine carnitine homeostasis in the blood of children with heart defects to see if it's disrupted. If it is, they plan to start clinical trials.

About 1 in 125 babies are born with a heart defect each year in the United States, according to the March of Dimes.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our cardiovascular / cardiology section for the latest news on this subject. The research was funded by the National Institutes of Health, the Foundation Leducq and the American Heart Association.
Medical College of Georgia at Georgia Regents University Please use one of the following formats to cite this article in your essay, paper or report:

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19 May. 2013. APA

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Saturday, May 11, 2013

Grape activate the genes of the antioxidant defence in the heart

Main category: Hypertension
Also included in: heart disease;??Nutrition / food;??Genetics
Article Date: May 6, 2013 - 1:00 PDT current ratings for:
Grape activate the genes of the antioxidant defence in the heart
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A study appearing in the Journal of nutrition Biochemistry1 shows that grapes are able to reduce heart failure associated with chronic high blood pressure (hypertension) by increasing the activity of several antioxidant defense genes in cardiac tissue. The grapes are a natural known source of antioxidants and other polyphenols, which researchers believe to be responsible for the beneficial effects observed with the consumption of grapes. This study, funded by a grant from the National Institutes of Health (NIH) and conducted at the University of Michigan health system, discovered a new way that grapes are beneficial in the heart: influencing the activities of gene and metabolic pathways that enhance glutathione, the cellular antioxidant levels more abundant in the heart.

About 1 billion people worldwide have high blood pressure, which increases the risk of heart failure by 2-3 times. Heart failure caused by chronic hypertension may cause a heart muscle becomes thick and rigid (fibrosis) and unable to fill with blood properly (diastolic dysfunction) or pump blood effectively. Oxidative stress is strongly correlated with heart failure, and Glutathione deficiency is regularly observed in heart failure models human and animal. A diet rich in antioxidants, containing plenty of fruits and vegetables, consistently correlate with reduced hypertension.

In this study, conducted at the University of Michigan health system, hypertension, congestive heart failure-prone submitted rats a diet rich in grapes for 18 weeks. Results reproduced the earlier findings that the consumption of grape reduces the occurrence of the enlargement of the heart muscle and the fibrosis and improvement of diastolic function of the heart. In addition, the mechanism of action was discovered: intake of antioxidant grape "lit" defence of ways, by increasing the activity of related genes that stimulate the production of glutathione.

"Our previous studies have shown that grapes may protect against the spiral of hypertensive heart failure, but how this has been achieved - the mechanism - was not yet known," said investigator main E. Mitchell Seymour, Ph. d. "lessons from our study of the NIH, including the ability to grapes to influence several genetic pathways related to antioxidant defenseprovide further evidence that grapes are working on several levels to deliver their beneficial effects. ?

Seymour noted that the next phase of the study of the NIH, which will continue into 2014, will allow his team to better define the mechanisms of action of grape and also to examine the impact of the contribution of whole grapes from different phytonutrients grape on hypertension associated with heart failure.

"Our hypothesis is that whole grapes will be greater than any component individual grape, in each of the areas studied," said Dr. Seymour. "The whole fruit contains hundreds of individual components, that we suspect likely to work together to provide a beneficial synergistic effect."

Lessons learned from this research will deepen the knowledge on the vine and the health of the heart, but also provide the Translational information on the value of dietetics (whole foods) and approaches to food supplement for the prevention of heart disease resulting from chronic hypertension.

"The NIH grant is allowing the team to the medical system of the University of Michigan to expand its activities in this important area and highlight the multiple role of grapes to support the health of the heart," said Kathleen Nave, Chairman of the California Table grape Commission. "This work will also key ideas in the role of wholes in relation to individual components of a fruit, using raisins as landmark".

Article adapted by Medical News Today press release original. Click on "references" tab above for the source.
Visit our section of hypertension for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper, or report:

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The University of Michigan Health System. "Grape activate genes involved in antioxidant defence in the heart." Medical news today. MediLexicon, international airport, may 6. 2013 Web.
May 6. 2013 APA

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