Also included in: heart disease;??Nutrition / food;??Genetics
Article Date: May 6, 2013 - 1:00 PDT current ratings for:
Grape activate the genes of the antioxidant defence in the heart
A study appearing in the Journal of nutrition Biochemistry1 shows that grapes are able to reduce heart failure associated with chronic high blood pressure (hypertension) by increasing the activity of several antioxidant defense genes in cardiac tissue. The grapes are a natural known source of antioxidants and other polyphenols, which researchers believe to be responsible for the beneficial effects observed with the consumption of grapes. This study, funded by a grant from the National Institutes of Health (NIH) and conducted at the University of Michigan health system, discovered a new way that grapes are beneficial in the heart: influencing the activities of gene and metabolic pathways that enhance glutathione, the cellular antioxidant levels more abundant in the heart.
About 1 billion people worldwide have high blood pressure, which increases the risk of heart failure by 2-3 times. Heart failure caused by chronic hypertension may cause a heart muscle becomes thick and rigid (fibrosis) and unable to fill with blood properly (diastolic dysfunction) or pump blood effectively. Oxidative stress is strongly correlated with heart failure, and Glutathione deficiency is regularly observed in heart failure models human and animal. A diet rich in antioxidants, containing plenty of fruits and vegetables, consistently correlate with reduced hypertension.
In this study, conducted at the University of Michigan health system, hypertension, congestive heart failure-prone submitted rats a diet rich in grapes for 18 weeks. Results reproduced the earlier findings that the consumption of grape reduces the occurrence of the enlargement of the heart muscle and the fibrosis and improvement of diastolic function of the heart. In addition, the mechanism of action was discovered: intake of antioxidant grape "lit" defence of ways, by increasing the activity of related genes that stimulate the production of glutathione.
"Our previous studies have shown that grapes may protect against the spiral of hypertensive heart failure, but how this has been achieved - the mechanism - was not yet known," said investigator main E. Mitchell Seymour, Ph. d. "lessons from our study of the NIH, including the ability to grapes to influence several genetic pathways related to antioxidant defenseprovide further evidence that grapes are working on several levels to deliver their beneficial effects. ?
Seymour noted that the next phase of the study of the NIH, which will continue into 2014, will allow his team to better define the mechanisms of action of grape and also to examine the impact of the contribution of whole grapes from different phytonutrients grape on hypertension associated with heart failure.
"Our hypothesis is that whole grapes will be greater than any component individual grape, in each of the areas studied," said Dr. Seymour. "The whole fruit contains hundreds of individual components, that we suspect likely to work together to provide a beneficial synergistic effect."
Lessons learned from this research will deepen the knowledge on the vine and the health of the heart, but also provide the Translational information on the value of dietetics (whole foods) and approaches to food supplement for the prevention of heart disease resulting from chronic hypertension.
"The NIH grant is allowing the team to the medical system of the University of Michigan to expand its activities in this important area and highlight the multiple role of grapes to support the health of the heart," said Kathleen Nave, Chairman of the California Table grape Commission. "This work will also key ideas in the role of wholes in relation to individual components of a fruit, using raisins as landmark".
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May 6. 2013
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